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While not really used in the medical world anymore, there is evidence that topical BPC 157 does in fact work

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• Extract-to-Synthetic Continuity: Epithalon was developed to reproduce the effects of Epithalamin, the bovine pineal extract — including lifespan extension in mice and fruit flies and restoration of melatonin and cortisol circadian rhythms in aged rhesus monkeys (PMID 12374906)