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It is reported that 5-ASA ameliorates UC in mice through dual mechanisms of preserving intestinal epithelial barrier integrity and modulating gut microbiota composition, with concomitant suprpression of JNK and p38 MAPK phosphorylation in colonic macrophages (Qu et al., 2017

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References Primary sources for this guide: PMID 39161060 (Diabetes, Obesity and Metabolism, 2024) for the mouse pharmacokinetics by intravenous, subcutaneous and oral routes, the 3.5% oral bioavailability, the 78 ng/mL mouse NNMT IC50, the hepatocyte stability data and the 28–30 day efficacy study