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R When the methylation cycle is impaired (MTHFR variants, B12/folate deficiency, BH4 depletion), SAH accumulates and inhibits COMT, HNMT, and other methyltransferases simultaneously

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Remarkably, glutamine completely blocked inflammation-induced apoptosis in the adult human epithelial cell line HT-29 when supplied at 0.5 mM, a concentration similar to that of free glutamine in human milk (115)