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7 medications that can cause heartburn Many common medications can cause or worsen heartburn symptoms, including: Antibiotics, such as tetracycline (including doxycycline) and clindamycin Benzodiazepines, such as Valium, Xanax, Halcion, Atavin and Klonopin Opioids, such as Percocet, codeine and OxyContin Calcium channel blockers, often prescribed for high blood pressure, and nitrates, given for chest pain Pain relievers, such as ibuprofen (Advil) and aspirin Bisphosphonates, given for osteoporosis Anticholinergics, prescribed for conditions including overactive bladder syndrome and irritable bowel syndrome, and for some symptoms of Parkinson’s disease 6 supplements that can cause heartburn Common supplements that rev up reflux include: Iron supplements Glucosamine Valerian Peppermint — though for some people, it eases heartburn, Olsen says
