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Pharmaceutical-grade pre-filled pens (Ozempic, Wegovy, Mounjaro, Zepbound) Different rules apply for pharma products: Ozempic pen: 56 days after first use (per FDA label) Wegovy pen: 28 days after first use Mounjaro/Zepbound pen: 28 days after first use Why longer: Pharmaceutical formulations include additional stabilizers not present in research peptides

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A separate 2004 fibroblast paper reported further cell divisions at the usual proliferative limit