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Research-grade tesamorelin is not approved for therapy or supplementation and falls under research chemical classifications, including WADA S0

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Blocking NNMT keeps nicotinamide in the NAD+ salvage pathway and S-adenosylmethionine available for polyamine synthesis, and in mouse models of diet-induced obesity that translates into smaller adipocytes, lower adipose mass, better oral glucose tolerance and less hepatic steatosis, with no measurable change in food intake