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As outlined earlier, GSTP exists as four functional allelic variants in humans: wild-type GSTP1*A (Ile105/Ala114), GSTP1*B (Val105/Ala114), GSTP1*C (Val105/Val114) and GSTP1*D (Ile105/Val114) [39] with GSTP1*B and GSTP1*C having lower catalytic activity than GSTP1*A [40]

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The median life span of saline-treated mice was 742 days, while that of semaglutide-treated mice was 834 days, a 12 percent increase