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Disease-modifying effects of metabolic perturbations in ALS/FTLD | Molecular Neurodegeneration | Springer Nature Link

(35596541, 33409766) Hyperammonemic encephalopathy, coma, or seizures

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GPX4 mainly protects cell membranes from oxidative attack, and studies have pointed out that there are three different subtypes, namely sperm karyotype, mitochondrial type and cytoplasmic type, which can catalyze complex lipid hydroperoxides such as phospholipids, cholesterol, and cholesterol esters in addition to H 2 O 2 (Bersuker et al., 2019)