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Loss of neurons associated with glutathione depletion has also been reported in rodents treated with morphine or heroin [13,14,15,16] but the evidence for equivalent depletion in human brains from opioid abusers is mixed, with one group reporting significant depletion [17,18] and another reporting none [19]

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These include approved prescription weight-loss medications based on synthetic peptides that mimic natural hormones, such as semaglutide and tirzepatide, found in weight loss drugs such as Wegovy and Mounjaro respectively