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For instance, NAD + levels and mitochondrial function have been shown to decline in sarcopenia muscle in one cohort 249 , while another study did not observe a difference in NAD + levels in sarcopenic muscle, and even NR supplementation had no effect on NAD + levels 262

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[DOI] [PMC free article] [PubMed] [Google Scholar] [148].Lash LH, Stemmer PM Renal Mitochondria as Sentinels for Exposures to Environmental Toxicants and Nephrotoxic Drugs