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Hematoxylin–eosin (H&E) and Masson’s trichrome staining techniques were performed on these sections to visualize the cellular structures

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Integrin αvβ3 is made of the αv and β3 chains and is expressed on skin cells, endothelial cells, macrophages, neutrophils, melanoma cells, and most cancer cells (Lygoe et al., 2004