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These include mGlu5 antagonists (fenobam), AMPA receptors (ampakines), and NMDA receptor inhibitors such as memantine, amantadine, and acamprosate [112, 145]

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Here are some key advantages of nasal spray delivery in the clinical setting: Fast Absorption : Nasal drug delivery provides rapid absorption into the bloodstream, typically achieving therapeutic levels within 15 to 30 minutes