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Additionally, supplementation of SCFAs to a high-fat diet (HFD) significantly reduced the release of gonadotropin-releasing hormone (GnRH) from the hypothalamus and delayed the development of the gonadal axis via the Kisspeptin-G protein-coupled receptor 54-protein kinase C-extracellular signal-regulated kinases 1/2 (Kiss1-GPR54-PKC-ERK1/2) pathway, thereby reversing obesity-induced precocious puberty in female rats (36)