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All changes to the MVP registrations described below are relative to our currently approved estimate of 6,285 registrations detailed in the CY 2025 PFS final rule (89 FR 98486 and 98487)

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TB-500 has been particularly extensively studied in cardiac repair models with foundational research demonstrating that thymosin beta-4 and TB-500 promote cardiomyocyte survival following ischaemia-reperfusion injury, stimulate cardiac progenitor cell migration into infarcted tissue, reduce infarct size, and improve cardiac function in myocardial infarction models