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PRDX6 selectively binds oxidized phospholipids, becomes membrane-associated, and executes coordinated membrane repair through reductive detoxification, iPLA 2 -mediated deacylation, and LPCAT-dependent reacylation with non-oxidized fatty acids

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Collectively, this study provides a solid foundation for future exploration into the impact of NNMTi-and diet-mediated changes to the gut microbiome in obese and lean populations, as well as future targets to investigate mechanistically with NNMTi treatment