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An example of modulating bioenergetics to improve physical function has been shown in preclinical studies of the small molecule 1,1-dimethylbiguanide hydrochloride, commonly known as metformin, which is a treatment for type 2 diabetes mellitus and a potent metabolic regulator that promotes improved responsiveness to insulin and aids in stabilizing blood glucose levels [453]

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Patch-clamp experiments demonstrated how melatonin is able to modulate NMDA receptor activity by the drastic attenuation of their currents in neurons located in the spinal cord dorsal horn 93