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The FOXO4 peptide in a DRI conformation (D-amino acids in a retro-reversed sequence), henceforth named FOXO4-DRI, competes with FOXO4 for p53 binding in a dose-dependent manner and doing so with higher affinity.

This gets the testes moving to ramp up testosterone levels

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In mild cases of deficiency when absorption is good, high-dose oral intakes can usually do the trick