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Inflammatory cytokines promote infiltration of neutrophils, macrophages and lymphocytes that further increase oxidative stress due to active exocytic, phagocytic, peroxisomal, and lysosomal functions

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Number of Tests:500 Assays

Certain IMPDH1 polymorphisms, such as nonsynonymous variants including rs2278294 and rs2228075, have been reported to reduce enzymatic activity through altered protein stability and impaired tetramer formation, without significantly affecting mRNA levels, indicating a post-translational regulatory mechanism