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Nanocarriers, such as ligand-functionalized lipid nanoparticles and MITO-Porter systems, can preferentially accumulate within mitochondria, facilitating the precise release of antioxidants and metabolic modulators (157)

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The adverse events were few with the herbal combination treatment compared to the tolerability and safety profiles of the reference drugs (5RI or alpha-1 blocker), which were included in two out of the four studies