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The ileum of these mice lost GSH-dependent activity to reduce peroxides and had increased expression of NOX1 mRNA and elevated levels of TNF, suggesting that NOX1 is the major source of ROS and further supporting the anti-inflammatory function of GPX1 and GPX2 [118]

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Higher concentrations (0.1% or above) risk copper overload on compromised skin, which can trigger the copper uglies: persistent redness, breakouts, and worsening sensitivity