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Global IGF-1R knockout embryos exhibit more severe skeletal defects than igf-1 null animals and die shortly after death, suggesting that both IGF-1 and IGF-2 acting via their shared receptor are involved in regulating skeletal development in the embryonic stage

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The vascular intima plays an important role in the homeostasis regulation of the vascular wall, including vascular tone, coagulation, inflammation, and permeability (53)