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Current knowledge indicates that astrocytes are critical for some cellular processes, such as the development and/or maintenance of blood–brain barrier characteristics, the promotion of neurovascular coupling, the attraction of cells through the release of chemokines, K + buffering, release of gliotransmitters, release of glutamate by calcium signaling, maintenance of general metabolism, control of the brain pH, metabolization of dopamine and other substrates by monoamine oxidases (MAOs