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SIRT1, SIRT6, and SIRT7 are predominantly found within the nucleus, while SIRT2 is predominantly cytoplasmic

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The distinct tissue architecture and healing dynamics in peri-implant environments may influence both the intensity and resolution of oxidative stress responses, underscoring the need for peri-implant–specific investigations to better define disease mechanisms and optimize therapeutic strategies ( 2.5 Systemic modifiers of local oxidative stress Systemic conditions such as diabetes mellitus, obesity, smoking, and aging significantly amplify oxidative stress within periodontal tissues